Publikationen des SFB1035 von 2016

B04: Oxidative unfolding of the rubredoxin domain and the natively disordered N-terminal region regulate the catalytic activity of Mycobacterium tuberculosis protein kinase G.
^{Wittwer Matthias, Luo Qi, Kaila Ville R. I., Dames Sonja A.}
J Biol Chem. 2016 Dec 30
doi: 10.1074/jbc.M116.747089 

 

A07: The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
^{Schmidt Christian, Kowalinski Eva, Shanmuganathan Vivekanandan, Defenouillère Quentin, Braunger Katharina, Heuer André, Pech Markus, Namane Abdelkader, Berninghausen Otto, Fromont-Racine Micheline, Jacquier Alain, Conti Elena, Becker Thomas, Beckmann Roland}
Science. 2016 Dec 16 
doi: 10.1126/science.aaf7520

 

A07: Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
^{Falk Sebastian, Finogenova Ksenia, Melko Mireille, Benda Christian, Lykke-Andersen Søren, Jensen Torben Heick, Conti Elena}
Nat Commun. 2016 Dec 1 
doi: 10.1038/ncomms13573

 

B03: Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation.
^{Mourão André, Bonnal Sophie, Soni Komal, Warner Lisa, Bordonné Rémy, Valcárcel Juan, Sattler Michael}
Elife. 2016 Nov 29
doi: 10.7554/eLife.14707

 

B03: Rational design of cyclic peptide inhibitors of U2AF Homology Motif (UHM) domains to modulate pre-mRNA splicing.
^{Jagtap Pravin Kumar Ankush, Garg Divita, Kapp Tobias G., Will Cindy L., Demmer Oliver, Lührmann Reinhard, Kessler Horst, Sattler Michael}
J Med Chem. 2016 Nov 23
doi: 10.1021/acs.jmedchem.6b01118

 

A03: Allosteric regulation points control the conformational dynamics of the molecular chaperone Hsp90.
^{Rehn Alexandra, Moroni Elisabetta, Zierer Bettina K., Tippel Franziska, Morra Giulia, John Christine, Richter Klaus, Colombo Giorgio, Buchner Johannes}
J Mol Biol. 2016 Nov 6
doi: 10.1016/j.jmb.2016.09.014

 

A03: Importance of cycle timing for the function of the molecular chaperone Hsp90.
^{Zierer Bettina K.,Rübbelke Martin, Tippel Franziska, Madl Tobias, Schopf Florian H., Rutz Daniel A., Richter Klaus, Sattler Michael, Buchner Johannes}
Nat Struct Mol Biol. 2016 Nov
doi: 10.1038/nsmb.3305

 

A11/B03: Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
^{Voith von Voithenberg Lena, Sánchez-Rico Carolina, Kang Hyun-Seo, Madl Tobias, Zanier Katia, Barth Anders, Warner Lisa R.,Sattler Michael, Lamb Don C.}
Proc Natl Acad Sci USA. 2016 Oct 31 
doi: 10.1073/pnas.1605873113

 

B03: Site-specific isotope-labeling of inosine phosphoramidites and NMR analysis of an inosine-containing RNA duplex.
^{Dallmann Andre, Beribisky Alexander V., Gnerlich Felix, Rübbelke Martin, Schiesser Stefan, Carell Thomas, Sattler Michael}
Chemistry. 2016 Oct 17
doi: 10.1002/chem.201602784

 

A06: The function of small heat-shock proteins and their implication in proteostasis.
^{Strauch Annika, Haslbeck Martin}
Essays Biochem. 2016 Oct 15
doi: 10.1042/EBC20160010

 

A06: Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aß42 toxicity in Drosophila.
^{Poska Helen, Haslbeck Martin, Kurudenkandy Firoz Roshan, Hermansson Erik, Chen Gefei, Kostallas George, Abelein Axel, Biverstål Henrik, Crux Sophie, Fisahn André, Presto Jenny, Johansson Jan}
Biochem J. 2016 Oct 15 
doi: 10.1042/BCJ20160277

 

B04: Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.
^{Wittwer Matthias, Dames Sonja A.}
Biomol NMR Assign. 2016 Oct
doi: 10.1007/s12104-016-9708-5

 

A01: Recent advances in the structural biology of the 26S proteasome.
^{Wehmer Marc, Sakata Eri}
Int J Biochem Cell Biol. 2016 Oct 
doi: 10.1016/j.biocel.2016.08.008

 

A10/A03: BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP.
^{Schneider Markus, Rosam, Mathias, Glaser Manuel, Patronov Atanas, Shah Harpreet, Back Katrin Christiane, Daake Marina Angelika, Buchner Johannes, Antes Iris}
Proteins. 2016 Oct 
doi: 10.1002/prot.25084

 

A04: The PsbY protein of Arabidopsis Photosystem II is important for the redox control of cytochrome b559.
^{von Sydow Lotta, Schwenkert Serena, Meurer Jörg, Funk Christiane, Mamedov Fikret, Schröder Wolfgang P.}
Biochim Biophys Acta. 2016 Sep 
doi: 10.1016/j.bbabio.2016.05.004

 

A06: Small heat shock proteins in bacteria.
^{Haslbeck, Martin}
in: Frans J. de Bruijn (Ed.) John Wiley & Sons, ‎Hoboken, New Jersey, Stress and Environmental Regulation of Gene Expression and Adaption in Bacteria, Chapter 71 pp 747-753 2016 August 26
doi: 10.1002/9781119004813.ch71

 

B02: Mechanism of pKID/KIX association studied by Molecular Dynamics free energy simulations.
^{Bomblies Rainer, Luitz  Manuel Patrick, Zacharias Martin}
J Phys Chem B. 2016 Aug 25
doi: 10.1021/acs.jpcb.6b01792
 

B05: bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
^{Rai Amrita, Oprisko Anastasia, Campos Jeremy, Fu Yangxue , Friese Timon, Itzen Aymelt, Goody Roger S., Gazdag Emerich Mihai, Müller Matthias P.}
Elife. 2016 Aug 23
doi: 10.7554/eLife.18675
 

 

A11: Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.
^{Crevenna Alvaro H., Blank Birgit, Maiser Andreas, Emin Derya, Prescher Jens, Beck Gisela, Kienzle Christine, Bartnik Kira, Habermann Bianca, Pakdel Mehrshad, Leonhardt Heinrich, Lamb Don C., von Blume Julia}
J Cell Biol. 2016 May 9
doi: 10.1083/jcb.201601089

 

A02/A10: Sequential inactivation of Gliotoxin by the S-Methyltransferase TmtA.
^{Duell Elke R., Glaser Manuel, Le Chapelain Camille, Antes Iris, Groll Michael, Huber Eva M.} 
ACS Chem Biol. 2016 Apr 15
doi: 10.1021/acschembio.5b00905

 

A04: Functional update of the auxiliary proteins PsbW, PsbY, HCF136, PsbN, TerC and ALB3 in maintenance and assembly of PSII.
^{Plöchinger Magdalena, Schwenkert Serena, von Sydow Lotta, Schröder Wolfgang P., Meurer Jörg}
Front Plant Sci. 2016 Apr 7 
doi: 10.3389/fpls.2016.00423

 

B07: Sulindac sulfide induces the formation of large oligomeric aggregates of the Alzheimer's disease amyloid-β peptide which exhibit reduced neurotoxicity.
^{Prade Elke, Barucker Christian, Sarkar Riddhiman, Althoff-Ospelt Gerhard, Lopez del Amo Juan Miguel, Hossain Shireen, Zhong Yifei, Multhaup Gerd, Reif Bernd}
Biochemistry. 2016 Mar 29 
doi: 10.1021/acs.biochem.5b01272

 

A06/B02/B07: A stable mutant predisposes antibody domains to amyloid formation through specific non-native interactions.
^{Nokwe Cardine N., Hora Manuel, Zacharias Martin, Yagi Hisashi, Peschek Jirka, Reif Bernd, Goto Yuji, Buchner Johannes}
J Mol Biol. 2016 Mar 27
doi: 10.1016/j.jmb.2016.01.015 

 

B03: Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
^{Janowski Robert, Heinz Gitta A., Schlundt Andreas, Wommelsdorf Nina, Brenner Sven, Gruber Andreas R., Blank Michael, Buch Thorsten, Buhmann Raymund, Zavolan Mihaela, Niessing Dierk, Heissmeyer Vigo, Sattler Michael}
Nat Commun. 2016 Mar 24
doi: 10.1038/ncomms11032 

 

A02: A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
^{Huber Eva M., Heinemeyer Wolfgang, Li Xia, Arendt Cassandra S., Hochstrasser Mark, Groll Michael}
Nat Commun. 2016 Mar 11
doi: 10.1038/ncomms10900 

 

B08/A03/ B09/B02: Regulatory implications of non-trivial splicing: Isoform 3 of Rab1A shows enhanced basal activity and is not controlled by accessory proteins.
^{Schöppner Patricia, Csaba Gergely, Braun Tatjana, Daake Marina, Richter Bettina, Lange Oliver F., Zacharias Martin, Zimmer Ralf, Haslbeck Martin}
J Mol Biol. 2016 Mar 4
doi: 10.1016/j.jmb.2016.02.028 

 

A05/B02: Subnanometre enzyme mechanics probed by single-molecule force spectroscopy.
^{Pelz Benjamin, Žoldák Gabriel, Zeller Fabian, Zacharias Martin, Rief Matthias}
Nat Commun. 2016 Feb 24
doi: 10.1038/ncomms10848 

 

A04: Roles of tetratricopeptide repeat proteins in biogenesis of the photosynthetic apparatus.
^{Bohne Alexandra-Viola, Schwenkert Serena, Grimm Bernhard, Nickelsen Jörg}
Int Rev Cell Mol Biol. 2016
doi: 10.1016/bs.ircmb.2016.01.005

 

A09: Barrel-shaped ClpP proteases display attenuated cleavage specificities.
^{Gersch Malte, Stahl Matthias, Poreba Marcin, Dahmen Maria, Dziedzic Anna, Drag Marcin, Sieber Stephan A.}
ACS Chem Biol. 2016 Feb 19
doi: 10.1021/acschembio.5b00757

 

B03: Improved accuracy from joint X-ray and NMR refinement of a protein-RNA complex structure.
^{Carlon Azzurra, Ravera Enrico, Hennig Janosch, Parigi Giacomo, Sattler Michael, Luchinat Claudio}
J Am Chem Soc. 2016 Feb 10
doi: 10.1021/jacs.5b11598

 

B02/B05: Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A Molecular Dynamics simulation analysis.
^{Luitz Manuel P., Bomblies Rainer, Ramcke Evelyn, Itzen Aymelt, Zacharias Martin}
Sci Rep. 2016 Jan 28
doi: 10.1038/srep19896
 

B02: Dynamics of seeded Aß40-fibril growth from atomistic Molecular Dynamics simulations: kinetic trapping and reduced water mobility in the locking step.
^{Schwierz Nadine, Frost Christina V., Geissler Phillip L., Zacharias Martin}
J Am Chem Soc. 2016 Jan 20
doi: 10.1021/jacs.5b08717
 

B03/Z1: Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
^{Feracci Mikael, Foot Jaelle N., Grellscheid Sushma N., Danilenko Marina, Stehle Ralf, Gonchar Oksana, Kang Hyun-Seo, Dalgliesh Caroline, Meyer N. Helge, Liu Yilei, Lahat Albert, Sattler Michael, Eperon Ian C., Elliott David J., Dominguez Cyril}
Nat Commun. 2016 Jan 13
doi: 10.1038/ncomms10355

 

B03/Z1: Inhibition of canonical NF-κB signaling by a small molecule targeting NEMO-ubiquitin interaction.
^{Vincendeau Michelle, Hadian Kamyar, Messias Ana C., Brenke Jara, Halander Jenny, Griesbach Richard, Greczmiel Ute, Bertossi Arianna, Stehle Ralf, Nagel Daniel, Demski Katrin, Velvarska Hana, Niessing Dierk, Geerlof Arie, Sattler Michael, Krappmann Daniel}
Sci Rep. 2016 Jan 7
doi: 10.1038/srep18934