Publikationen des SFB1035 von 2017
A01: Proteasomes tether to two distinct sites at the nuclear pore complex.
Albert Sahradha, Schaffer Miroslava, Beck Florian, Mosalaganti Shyamal, Asano Shoh, Thomas Henry F., Plitzko Jürgen M., Beck Martin, Baumeister Wolfgang, Engel Benjamin D.
Proc Natl Acad Sci USA. 2017 Dec 26
doi: 10.1073/pnas.1716305114
A12: Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2.
Aigner Harald, Wilson Richard H., Bracher Andreas, Calisse Lorenzo, Bhat Javaid Y., Hartl F. Ulrich, Hayer-Hartl Manajit
Science. 2017 Dec 8
doi: 10.1126/science.aap9221
A09: A chemical disruptor of the ClpX chaperone complex attenuates the virulence of multidrug-resistant Staphylococcus aureus.
Fetzer Christian, Korotkov Vadim S., Thänert Robert, Lee Kyu Myung, Neuenschwander Martin, von Kries Jens Peter, Medina Eva, Sieber Stephan A.
Angew Chem Int Ed Engl. 2017 Dec 4
doi: 10.1002/anie.201708454
B10/B05: Proximity-triggered covalent stabilization of low-affinity protein complexes in vitro and in vivo.
Cigler Marko, Müller Thorsten G., Horn-Ghetko Daniel, von Wrisberg Marie-Kristin, Fottner Maximilian, Goody Roger S., Itzen Aymelt, Müller Matthias P., Lang Kathrin
Angew Chem Int Ed Engl. 2017 Dec 4
doi: 10.1002/anie.201706927
A07/B03: Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53.
Falk Sebastian, Tants Jan-Niklas, Basquin Jerôme, Thoms Matthias, Hurt Ed, Sattler Michael, Conti Elena
RNA. 2017 Dec
doi: 10.1261/rna.062901.117
B07/B13: Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.
Rodriguez Camargo Diana C., Korshavn Kyle J., Jussupow Alexander, Raltchev Kolio, Goricanec David, Fleisch Markus, Sarkar Riddhiman, Xue Kai, Aichler Michaela, Mettenleiter Gabriele, Walch Axel Karl, Camilloni Carlo, Hagn Franz, Reif Bernd, Ramamoorthy Ayyalusamy
Elife. 2017 Nov 17
doi: 10.7554/eLife.31226
A03/A09: A chemical compound inhibiting the Aha1-Hsp90 chaperone complex.
Stiegler Sandrine C., Rübbelke Martin, Korotkov Vadim S., Weiwad Matthias, John Christine, Fischer Gunter, Sieber Stephan A., Sattler Michael, Buchner Johannes
J Biol Chem. 2017 Oct 13
doi: 10.1074/jbc.M117.797829
Z1: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
Tants Jan-Niklas, Fesser Stephanie, Kern Thomas, Stehle Ralf, Geerlof Arie, Wunderlich Christoph, Juen Michael, Hartlmüller Christoph, Böttcher Romy, Kunzelmann Stefan, Lange Oliver F., Kreutz Christoph, Förstemann Klaus, Sattler Michael
Nucleic Acids Res. 2017 Oct 13
doi: 10.1093/nar/gkx886
B03/A11: Effects of fluorophore attachment on protein conformation and dynamics studied by spFRET and NMR spectroscopy.
Sánchez-Rico Carolina, Voith von Voithenberg Lena, Warner Lisa, Lamb Don C., Sattler Michael
Chemistry. 2017 Oct 12
doi: 10.1002/chem.201702423
B02: Comparative molecular dynamics analysis of RNase-S complex formation.
Luitz Manuel P., Bomblies Rainer, Zacharias Martin
Biophys J. 2017 Oct 3
doi: 10.1016/j.bpj.2017.08.008
B03/A07: Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53.
Falk Sebastian, Tants Jan-Niklas, Basquin Jerôme, Thoms Matthias, Hurt Ed, Sattler Michael, Conti Elena
RNA. 2017 Sep 7
doi: 10.1261/rna.062901.117
A03: The plasticity of the Hsp90 co-chaperone system.
Sahasrabudhe Priyanka, Rohrberg Julia, Biebl Maximillian M., Rutz Daniel A., Buchner Johannes
Mol Cell. 2017 Sep 6
doi: 10.1016/j.molcel.2017.08.004
A07: Mpp6 incorporation in the nuclear exosome contributes to RNA channeling through the Mtr4 helicase.
Falk Sebastian, Bonneau Fabien, Ebert Judit, Kögel Alexander, Conti Elena
Cell Rep. 2017 Sep 5
doi: 10.1016/j.celrep.2017.08.033
A02: The mammalian proteasome activator PA28 forms an asymmetric α4β3 complex.
Huber Eva M., Groll Michael
Structure. 2017 Aug 22
doi: 10.1016/j.str.2017.07.013
B07: Limits of resolution and sensitivity of proton detected MAS solid-state NMR experiments at 111 kHz in deuterated and protonated proteins.
Xue Kai, Sarkar Riddhiman, Motz Carina, Asami Sam, Rodriguez Camargo Diana C., Decker Venita, Wegner Sebastian, Tošner Zdeněk, Reif Bernd
Sci Rep. 2017 Aug 7
doi: 10.1038/s41598-017-07253-1
Z1: Segmental, domain-selective perdeuteration and small-angle neutron scattering for structural analysis of multi-domain proteins.
Sonntag Miriam, Jagtap Pravin Kumar Ankush, Simon Bernd, Appavou Marie-Sousai, Geerlof Arie, Stehle Ralf, Gabel Frank, Hennig Janosch, Sattler Michael
Angew Chem Int Ed Engl. 2017 Aug 1
doi: 10.1002/anie.201702904
B03: RNA structure refinement using NMR solvent accessibility data.
Hartlmüller Christoph, Günther Johannes C., Wolter Antje C., Wöhnert Jens, Sattler Michael, Madl Tobias
Sci Rep. 2017 Jul 14
doi: 10.1038/s41598-017-05821-z
B06/B02: Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly.
Bakou Maria, Hille Kathleen, Kracklauer Michael, Spanopoulou Anna, Frost Christina V., Malideli Eleni, Yan Li-Mei, Caporale Andrea, Zacharias Martin, Kapurniotu Aphrodite
J Biol Chem. 2017 Jul 6
doi: 10.1074/jbc.M117.774893
A07: Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.
Li Liang, Lingaraju Mahesh, Basquin Claire, Basquin Jérome, Conti Elena
RNA. 2017 Jul
doi: 10.1261/rna.061200.117
A06: An alternative splice variant of human αA-crystallin modulates the oligomer ensemble and the chaperone activity of α-crystallins.
Preis Waldemar, Bestehorn Annika, Buchner Johannes, Haslbeck Martin
Cell Stress Chaperones. 2017 Jul
doi: 10.1007/s12192-017-0772-2
A07: Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
Leonaite Bronislava, Han Zhong, Basquin Jérôme, Bonneau Fabien, Libri Domenico, Porrua Odil, Conti Elena
EMBO J. 2017 Jun 1
doi: 10.15252/embj.201696174
A03: The HSP90 chaperone machinery.
Schopf Florian H., Biebl Maximilian M., Buchner Johannes
Nat Rev Mol Cell Biol. 2017 Jun
doi: 10.1038/nrm.2017.20
B02/A11: Covalent dye attachment influences the dynamics and conformational properties of flexible peptides.
Luitz Manuel P., Barth Anders, Crevenna Alvaro H., Bomblies Rainer, Lamb Don C., Zacharias Martin
PLoS One. 2017 May 23
doi: 10.1371/journal.pone.0177139
A05: Nanomechanics of the substrate binding domain of Hsp70 determine its allosteric ATP-induced conformational change.
Mandal Soumit Sanka, Merz Dale R., Buchsteiner Maximilian, Dima Ruxandra I., Rief Matthias, Žoldák Gabriel
Proc Natl Acad Sci USA. 2017 May 22
doi: 10.1073/pnas.1619843114
A01: Molecular details underlying dynamic structures and regulation of the human 26S proteasome.
Wang Xiaorong, Cimermancic Peter, Yu Clinton, Schweitzer Andreas, Chopra Nikita, Engel James L., Greenberg Charles, Huszagh Alexander S., Beck Florian, Sakata Eri, Yang Yingying, Novitsky Eric J., Leitner Alexander, Nanni Paolo, Kahraman Abdullah, Guo Xing, Dixon Jack E., Rychnovsky Scott D., Aebersold Ruedi, Baumeister Wolfgang, Sali Andrej, Huang Lan
Mol Cell Proteomics. 2017 May
doi: 10.1074/mcp.M116.065326
Z1: Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
Schlundt Andreas, Buchner Sophie, Janowski Robert, Heydenreich Thomas, Heermann Ralf, Lassak Jürgen, Geerlof Arie, Stehle Ralf, Niessing Dierk, Jung Kirsten, Sattler Michael
Sci Rep. 2017 Apr 21
doi: 10.1038/s41598-017-01031-9
B02: Molecular Dynamics analysis of 4E-BP2 protein fold stabilization induced by phosphorylation.
Bomblies Rainer, Luitz Manuel P., Zacharias Martin
J Phys Chem B. 2017 Apr 20
doi: 10.1021/acs.jpcb.6b08597
B03: Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition.
Schlundt Andreas, Tants Jan-Niklas, Sattler Michael
Methods. 2017 Apr 15
doi: 10.1016/j.ymeth.2017.03.015
A12: Rubisco activases: AAA+ chaperones adapted to enzyme repair.
Bhat Javaid Y., Thieulin-Pardo Gabriel, Hartl F. Ulrich, Hayer-Hartl Manajit
Front Mol Biosci. 2017 Apr 10
doi: 10.3389/fmolb.2017.00020
B02: Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and Molecular Dynamics simulations.
Bomblies Rainer, Luitz Manuel Patrick, Scanu Sandra, Madl Tobias, Zacharias Martin
PLoS One. 2017 Mar 29
doi: 10.1371/journal.pone.0174337
B11: Assembly-induced folding regulates interleukin 12 biogenesis and secretion.
Reitberger Susanne, Haimerl Pascal, Aschenbrenner Isabel, Esser-von Bieren Julia, Feige Matthias J.
J Biol Chem. 2017 Mar 21
doi: 10.1074/jbc.M117.782284
A02: Structural elucidation of a nonpeptidic inhibitor specific for the human immunoproteasome.
Cui Haissi, Baur Regina, Le Chapelain Camille, Dubiella Christian, Heinemeyer Wolfgang, Huber Eva M., Groll Michael
Chembiochem. 2017 Mar 16
doi: 10.1002/cbic.201700021
B12/A03: Hsp90 dependence of a kinase is determined by its conformational landscape.
Luo Qi, Boczek Edgar E., Wang Qi, Buchner Johannes, Kaila Ville R. I.
Sci Rep. 2017 Mar 14
doi: 10.1038/srep43996
B07: The redox environment triggers conformational changes and aggregation of hIAPP in type II diabetes.
Rodriguez Camargo Diana C., Tripsianes Konstantinos, Buday Katalin, Franko Andras, Göbl Christoph, Hartlmüller Christoph, Sarkar Riddhiman, Aichler Michaela, Mettenleiter Gabriele, Schulz Michael, Böddrich Annett, Erck Christian, Martens Henrik, Walch Axel Karl, Madl Tobias, Wanker Erich E., Conrad Marcus, Hrabě de Angelis Martin, Reif Bernd
Sci Rep. 2017 Mar 13
doi: 10.1038/srep44041
A09: Quantitative map of β-lactone-induced virulence regulation.
Krysiak Joanna, Stahl Matthias, Vomacka Jan, Fetzer Christian, Lakemeyer Markus, Fux Anja, Sieber Stephan A.
J Proteome Res. 2017 Mar 3
doi: 10.1021/acs.jproteome.6b00705
A01: Structural insights into the functional cycle of the ATPase module of the 26S proteasome.
Wehmer Marc, Rudack Till, Beck Florian, Aufderheide Antje, Pfeifer Günter, Plitzko Jürgen M., Förster Friedrich, Schulten Klaus, Baumeister Wolfgang, Sakata Eri
Proc Natl Acad Sci USA. 2017 Feb 7
doi: 10.1073/pnas.1621129114
B02: Monte Carlo replica-exchange based ensemble docking of protein conformations.
Zhang Zhe, Ehmann Uwe, Zacharias Martin
Proteins. 2017 Feb 7
doi: 10.1002/prot.25262
A10: DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.
Hoffmann Thomas, Marion Antoine, Antes Iris
BMC Struct Biol. 2017 Feb 2
doi: 10.1186/s12900-016-0071-7
A09: Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes.
Balogh Dóra, Dahmen Maria, Stahl Matthias, Poreba Marcin, Gersch Malte, Drag Marcin, Sieber Stephan A.
Chem Sci. 2017 Feb 1
doi: 10.1039/c6sc03438a
B03/Z1: Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Edelmann Franziska, Schlundt Andreas, Heym Roland Gerhard, Jenner Andreas, Niedner-Boblenz Annika, Syed Muhammad Ibrahim, Paillart Jean-Christophe, Stehle Ralf, Janowski Robert, Sattler Michael, Jansen Ralf-Peter, Niessing Dierk
Nat Struct Mol Biol. 2017 Feb
doi: 10.1038/nsmb.3351
A06: The chaperone activity and substrate spectrum of human small heat shock proteins.
Mymrikov Evgeny V., Daake Marina, Richter Bettina, Haslbeck Martin, Buchner Johannes
J Biol Chem. 2017 Jan 13
doi: 10.1074/jbc.M116.760413
B13: Covalently circularized nanodiscs for studying membrane proteins and viral entry.
Nasr Mahmoud L., Baptista Diego, Strauss Mike, Sun Zhen-Yu J., Grigoriu Simina, Huser Sonja, Plückthun Andreas, Hagn Franz, Walz Thomas, Hogle James M., Wagner Gerhard
Nat Methods. 2017 Jan
doi: 10.1038/nmeth.4079
B10: Tetrazines in inverse-electron-demand Diels–Alder cycloadditions and their use in biology
Mayer Susanne, Lang Kathrin
Synthesis 2017
doi: 10.1055/s-0036-1588682