P04 Busch, Holler
T cell skewing in relation to intestinal dysbiosis and GvHD in allogeneic stem cell transplantation
Principal Investigators:
Busch, Dirk, TUM
Holler, Ernst, UKR
The key hypothesis of this project is that microbiota dysbiosis skews the reconstitution of a regulatory immune response in the gut and both contribute to development of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (aHSTC). This connection provides the rationale for reverting dysbiosis and the loss of regulatory T cells as a potent treatment of GvHD. We aim to identify changes in microbiota signatures, mucosal lymphocyte populations and T cell receptor repertoire composition associated with clinical outcome, taking advantage of a unique collection of gut biopsies longitudinally collected over the course of GvHD onset and development, including patients before and after fecal transplantation (FMT).
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