P10 Janssen, Zeissig
Microbiota- and TLR-dependent regulation of intestinal tumor development
Principal Investigators:
Janssen, Klaus-Peter, TUM
Zeissig, Sebastian, TUD
Microbial factors can either promote or inhibit intestinal tumor development through activation of various TLR (toll-like-receptor)-dependent pathways. Here we aim to analyze whether specific microbial taxa are responsible for promoting tumor compared to tumor-suppressive effects in mouse models of colorectal cancer (CRC). We also aim to dissect the tumor-suppressive effects of TRIF/TLR3 signaling with the help of genetically engineered mouse models. The translational relevance of the preclinical findings will be evaluated using two large, independent human CRC cohorts.
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