P13 Ecker, Klingenspor
Impact of dietary fat / gut microbiota interaction on intestinal lipid absorption, systemic lipid metabolism and intestinal cancer
Principal Investigators:
Ecker, Josef, TUM
Klingenspor, Martin, TUM
We aim to reveal the role of dietary fat / microbiota interaction on lipid metabolism. Mouse models with different microbiota status and intestinal cancer susceptibility will receive diets with varying dietary fat content and lipid composition. Obesity and cancer progression will be determined and bioactive lipids identified by mass-spectrometric lipid analytics, also applying stable isotope labeled tracers. Our goal is to define dietary lipid compositions and gut microbiota communities beneficial in the suppression of obesity-driven metabolic diseases and intestinal cancer.
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