Collaborative Research Center 1035 – Control of protein function by conformational switching

Structural plasticity and conformational dynamics are hallmarks of proteins. Delineating the mechanisms of conformational switches in proteins, tightly controlled by various factors and processes, is key to unravel the principles that shape our protein universe. The CRC1035 combines researchers with complementary expertise in advanced biochemical and biophysical methods and employs interdisciplinary approaches to determine the underlying molecular mechanisms. Analysis of model systems has provided an understanding of basic principles of conformational switches. The progress achieved forms the basis for analysing the specific mechanisms of conformational switching in the regulation of protein function in medically relevant assemblies and systems linked to (patho)physiological conditions.