Publikationen des SFB1035 von 2015

A03: Hsp90·Cdc37 complexes with protein kinases form cooperatively with multiple distinct interaction sites.
^{Eckl Julia M., Scherr Matthias J., Freiburger Lee, Daake Marina A., Sattler Michael, Richter Klaus}
J Biol Chem. 2015 Dec 25
doi: 10.1074/jbc.M115.693150 

 

A02: Selective inhibition of the immunoproteasome by structure-based targeting of a non-catalytic cysteine.
^{Dubiella Christian, Baur Regina, Cui Haissi, Huber Eva M., Groll Michael}
Angew Chem Int Ed Engl. 2015 Dec 21
doi: 10.1002/anie.201506631 

 

A09/A02: Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association.
^{Pahl Axel, Lakemeyer Markus, Vielberg Marie-Theres, Hackl Mathias W., Vomacka Jan, Korotkov Vadim S., Stein Martin L., Fetzer Christian, Lorenz-Baath Katrin, Richter Klaus, Waldmann Herbert, Groll Michael, Sieber Stephan A.}
Angew Chem Int Ed Engl. 2015 Dec 21
doi: 10.1002/anie.201507266

 

B07: Structural mechanism of the interaction of Alzheimer disease Aß fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) sulindac sulfide.
^{Prade Elke, Bittner Heiko J., Sarkar Riddhiman, Lopez del Amo Juan Miguel, Althoff-Ospelt Gerhard, Multhaup Gerd, Hildebrand Peter W., Reif Bernd}
J Biol Chem. 2015 Nov 27
doi: 10.1074/jbc.M115.675215

 

B05: Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
^{Lai Yu-Chiang, Kondapalli Chandana, Lehneck Ronny, Procter James B., Dill Brian D., Woodroof Helen I., Gourlay Robert, Peggie Mark, Macartney Thomas J., Corti Olga, Corvol Jean-Christophe, Campbell David G., Itzen Aymelt, Trost Matthias, Muqit Miratul MK.}
EMBO J. 2015 Nov 12
doi: 10.15252/embj.201591593

 

B03: Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.
^{Horn Annemarie, Hennig Janosch, Ahmed Yasar L., Stier Gunter, Wild Klemens, Sattler Michael, Sinning Irmgard}
Nat Commun. 2015 Nov 16
doi: 10.1038/ncomms9875

 

A07: Structure of the RNA helicase MLE reveals the molecular mechanisms for uridine specificity and RNA-ATP coupling.
^{Prabu J. Rajan, Müller Marisa, Thomae Andreas W., Schüssler Steffen, Bonneau Fabien, Becker Peter B., Conti Elena}
Mol Cell. 2015 Nov 5 
doi: 10.1016/j.molcel.2015.10.011

 

B02: Substrate binding specifically modulates domain arrangements in adenylate kinase.
^{Zeller Fabian, Zacharias Martin}
Biophys J. 2015 Nov 3
doi: 10.1016/j.bpj.2015.08.049 

 

B07/A06/B03: The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client.
^{Mainz Andi, Peschek Jirka, Stavropoulou Maria, Back Katrin C., Bardiaux Benjamin, Asami Sam, Prade Elke, Peters Carsten, Weinkauf Sevil, Buchner Johannes, Reif Bernd}
Nat Struct Mol Biol. 2015 Nov
doi: 10.1038/nsmb.3108

 

A07: Structure of a human 4E-T/DDX6/CNOT1 complex reveals the different interplay of DDX6-binding proteins with the CCR4-NOT complex.
^{Özgür Sevim, Basquin Jérôme, Kamenska Anastasiia, Filipowicz Witold, Standart Nancy, Conti Elena}
Cell Rep 2015 Oct 27
doi: 10.1016/j.celrep.2015.09.033

 

B08: Alternative splicing in next generation sequencing data of Saccharomyces cerevisiae.
^{Schreiber Konrad, Csaba Gergely, Haslbeck Martin, Zimmer Ralf}
PLoS One. 2015 Oct 15
doi: 10.1371/journal.pone.0140487 

 

B06/B07: A hot-segment-based approach for the design of cross-amyloid interaction surface mimics as inhibitors of amyloid self-assembly.
^{Andreetto Erika, Malideli Eleni, Yan Li-Mei, Kracklauer Michael, Farbiarz Karine, Tatarek-Nossol Marianna, Rammes Gerhard, Prade Elke, Neumüller Tatjana, Caporale Andrea, Spanopoulou Anna, Bakou Maria, Reif Bernd, Kapurniotu Aphrodite}
Angew Chem Int Ed Engl. 2015 Sep 4
doi: 10.1002/anie.201504973 

 

A03: Efficient segmental isotope labeling of multi-domain proteins using Sortase A.
^{Freiburger Lee, Sonntag Miriam, Hennig Janosch, Li Jian, Zou Peijian, Sattler Michael}
J Biomol NMR. 2015 Sep
doi: 10.1007/s10858-015-9981-0

 

A04: The extreme Albino3 (Alb3) C terminus is required for Alb3 stability and function in Arabidopsis thaliana.
^{Urbischek Manuela, Nick von Braun Sabine, Brylok Thomas, Gügel Irene L., Richter Andreas, Koskela Minna, Grimm Bernhard, Mulo Paula, Bölter Bettina, Soll Jürgen, Ankele Elisabeth, Schwenkert Serena}
Planta. 2015 Sep
doi: 10.1007/s00425-015-2352-y

 

B02: Exploring biomolecular dynamics and interactions using advanced sampling methods.
^{Luitz Manuel, Bomblies Rainer, Ostermeir Katja, Zacharias Martin}
J Phys Condens Matter. 2015 Aug 19
doi: 10.1088/0953-8984/27/32/323101 

 

A05: Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK.
^{Bauer Daniela, Merz Dale R., Pelz Benjamin, Theisen Kelly E., Yacyshyn Gail, Mokranjac Dejana, Dima Ruxandra I., Rief Matthias, Žoldák Gabriel}
Proc Natl Acad Sci USA. 2015 Aug 18
doi: 10.1073/pnas.1504625112

 

B02: Free energy calculations of ligand-protein binding.
^{Luitz Manuel, Bomblies Rainer, Zacharias Martin}
in: Cavasotto Claudio N. (Ed.), Taylor and Francis Press, In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications, Chapter 12, pp 533-555, 2015 August 6
ISBN-13: 978-1482217834 

 

A05: Ligand-induced changes of the apparent transition-state position in mechanical protein unfolding.
^{Stigler Johannes, Rief Matthias}
Biophys J. 2015 Jul 21
doi: 10.1016/j.bpj.2015.06.009

 

A10: Quantitative analysis of the association angle between T-cell receptor Vα/Vβ domains reveals important features for epitope recognition.
^{Hoffmann Thomas, Krackhardt Angela M., Antes Iris}
PLoS Comput Biol. 2015 Jul 17
doi: 10.1371/journal.pcbi.1004244 

 

B05: Locking GTPases covalently in their functional states.
^{Wiegandt David, Vieweg Sophie, Hofmann Frank, Koch Daniel, Li Fu, Wu Yao-Wen, Itzen Aymelt, Müller Matthias P., Goody Roger S.}
Nat Commun. 2015 Jul 16
doi: 10.1038/ncomms8773

 

A01: Structural characterization of the interaction of Ubp6 with the 26S proteasome.
^{Aufderheide Antje, Beck Florian, Stengel Florian, Hartwig Michaela, Schweitzer Andreas, Pfeifer Günter, Goldberg Alfred L., Sakata Eri, Baumeister Wolfgang, Förster Friedrich}
Proc Natl Acad Sci USA. 2015 Jul 14 
doi: 10.1073/pnas.1510449112

 

B08: Count ratio model reveals bias affecting NGS fold changes.
^{Erhard Florian, Zimmer Ralf}
Nucleic Acids Res. 2015 Jul 8
doi: 10.1093/nar/gkv696 

 

B05: Covalent protein labeling by enzymatic phosphocholination.
^{Heller Katharina, Ochtrop Philipp, Albers Michael F., Zauner Florian B., Itzen Aymelt, Hedberg Christian}
Angew Chem Int Ed Engl. 2015 Jul 3
doi: 10.1002/anie.201502618

 

B04: Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G.
^{Wittwer Matthias, Dames Sonja A.}
Protein Expr Purif. 2015 Jul
doi: 10.1016/j.pep.2015.03.015 

 

A06: Regulation of the chaperone function of small Hsps.
^{Haslbeck Martin, Weinkauf Sevil, Buchner Johannes}
in: Tanguay Robert M., Hightower Lawrence E. (Eds.), Springer, Switzerland, The Big Book on Small Heat Shock Proteins, Chapter 6, pp 155-178, 2015 Jun 27
doi: 10.1007/978-3-319-16077-1_6

 

A06: Structure and function of α-crystallins: Traversing from in vitro to in vivo.
^{Haslbeck Martin, Peschek Jirka, Buchner Johannes, Weinkauf Sevil}
Biochim Biophys Acta. 2015 Jun 25
doi: 10.1016/j.bbagen.2015.06.008 

 

A06/A02: The chaperone activity of the developmental small heat shock protein Sip1 is regulated by pH-dependent conformational changes.
^{Fleckenstein Tilly, Kastenmüller Andreas, Stein Martin Lorenz, Peters Carsten, Daake Marina, Krause Maike, Weinfurtner Daniel, Haslbeck Martin, Weinkauf Sevil, Groll Michael, Buchner Johannes}
Mol Cell. 2015 Jun 18
doi: 10.1016/j.molcel.2015.04.019 

 

B03: Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology.
^{Hennig Janosch, Sattler Michael}
Bioessays. 2015 Jun 8
doi: 10.1002/bies.201500033

 

B09/B02: Application of enhanced sampling Monte Carlo methods for high-resolution protein-protein docking in Rosetta.
^{Zhang Zhe, Schindler Christina E. M., Lange Oliver F., Zacharias Martin}
PLoS One. 2015 Jun 8
doi: 10.1371/journal.pone.0125941 

 

A03: Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.
^{Boczek Edgar E., Reefschläger Lasse G., Dehling Marco, Struller Tobias J., Häusler Elisabeth, Seidl Andreas, Kaila Ville R. I., Buchner Johannes}
Proc Natl Acad Sci USA. 2015 Jun 8
doi: 10.1073/pnas.1424342112 

 

A06: Medical implications of understanding the functions of human small heat shock proteins.
^{Mymrikov Evgeny V., Haslbeck Martin}
Expert Rev Proteomics. 2015 Jun
doi: 10.1586/14789450.2015.1039993 

 

B04: One short cysteine-rich sequence pattern - two different disulfide-bonded structures - a molecular dynamics simulation study.
^{Dames Sonja A.}
J Pept Sci. 2015 Jun
doi: 10.1002/psc.2765 

 

B03: The EBNA-2 N-terminal transactivation domain folds into a dimeric structure required for target gene activation.
^{Friberg Anders, Thumann Sybille, Hennig Janosch, Zou Peijian, Nössner Elfriede, Ling Paul D., Sattler Michael, Kempkes Bettina}
PLoS Pathog. 2015 May 29
doi: 10.1371/journal.ppat.1004910 

 

B03: A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.
^{Anosova Irina, Melnik Svitlana, Tripsianes Konstantinos, Kateb Fatiha, Grummt Ingrid, Sattler Michael}
Nucleic Acids Res. 2015 May 26
doi: 10.1093/nar/gkv365

 

A04: Phosphomimicking within the transit peptide of pHCF136 leads to reduced photosystem II accumulation in vivo.
^{Nickel Catharina, Soll Jürgen, Schwenkert Serena}
FEBS Lett. 2015 May 22
doi: 10.1016/j.febslet.2015.04.033

 

A07: Architecture of the ubiquitylation module of the yeast ccr4-not complex.
^{Bhaskar Varun, Basquin Jérôme, Conti Elena}
Structure. 2015 May 5
doi: 10.1016/j.str.2015.03.011

 

B08: A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
^{Haslbeck Martin, Vierling Elizabeth}
J Mol Biol. 2015 Apr 10
doi: 10.1016/j.jmb.2015.02.00 

 

A03/A11: Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.
^{Röhl Alina, Wengler Daniela, Madl Tobias, Lagleder Stephan, Tippel Franziska, Herrmann Monika, Hendrix Jelle, Richter Klaus, Hack Gordon, Schmid Andreas B., Kessler Horst, Lamb Don C., Buchner Johannes}
Nat Commun. 2015 Apr 8
doi: 10.1038/ncomms7655

 

B07: Site-specific solid-state NMR studies of "trigger factor" in complex with the large ribosomal subunit 50S.
^{Barbet-Massin Emeline, Huang Chih-Ting, Daebel Venita, Hsu Shang-Te Danny, Reif Bernd}
Angew Chem Int Ed Engl. 2015 Mar 27
doi: 10.1002/anie.201409393

 

A09/A02: Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes.
^{Dahmen Maria, Vielberg Marie-Theres, Groll Michael, Sieber Stephan A.}
Angew Chem Int Ed Engl. 2015 Mar 16
doi: 10.1002/anie.201409325

 

A07: The conformational plasticity of eukaryotic RNA-dependent ATPases.
^{Özgür Sevim, Buchwald Gretel, Falk Sebastian, Chakrabarti Sutapa, Prabu Jesuraj Rajan, Conti Elena}
FEBS J. 2015 Mar
doi: 10.1111/febs.13198 

 

A03: A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
^{Riebold Mathias, Kozany Christian, Freiburger Lee, Sattler Michael, Buchfelder Michael, Hausch Felix, Stalla Günter K., Paez-Pereda Marcelo}
Nat Med. 2015 Mar
doi: 10.1038/nm.3776 

 

B03: Structural analysis of protein-RNA complexes in solution using NMR paramagnetic relaxation enhancements.
^{Hennig Janosch, Warner Lisa R., Simon Bernd, Geerlof Arie, Mackereth Cameron D., Sattler Michael}
Methods Enzymol. 2015
doi: 10.1016/bs.mie.2015.02.006

 

B04: Subtype-specific modulation of estrogen receptor-coactivator interaction by phosphorylation.
^{Tharun Inga M., Nieto Lidia, Haase Christian, Scheepstra Marcel , Balk Mark, Möcklinghoff Sabine, Adriaens Wencke, Dames Sonja A., Brunsveld Luc}
ACS Chem Biol. 2015 Feb 20
doi: 10.1021/cb5007097 

 

A03/B05: Hop/Sti1 phosphorylation inhibits its co-chaperone function.
^{Röhl Alina, Tippel Franziska, Bender Evelyn, Schmid Andreas B., Richter Klaus, Madl Tobias, Buchner Johannes}
EMBO Rep. 2015 Feb
doi: 10.15252/embr.201439198 

 

B07: Cloning, expression and purification of the human Islet Amyloid Polypeptide (hIAPP) from Escherichia coli.
^{Rodriguez Camargo Diana C., Tripsianes Konstantinos, Kapp Tobias G., Mendes Joaquim, Schubert Jasmin, Cordes Burghard, Reif Bernd}
Protein Expr Purif. 2015 Feb
doi: 10.1016/j.pep.2014.10.012

 

B07/B09/B03: Access to Cα backbone dynamics of biological solids by 13C T1 relaxation and molecular dynamics simulation.
^{Asami Sam, Porter Justin R., Lange Oliver F., Reif Bernd}
J Am Chem Soc. 2015 Jan 28
doi: 10.1021/ja509367q

 

A04: Redox meets protein trafficking.
^{Bölter Bettina, Soll Jürgen, Schwenkert Serena}
Biochim Biophys Acta. 2015 Jan 24
doi: 10.1016/j.bbabio.2015.01.010 

 

A01: Proteasomes. A molecular census of 26S proteasomes in intact neurons.
^{Asano Shoh, Fukuda Yoshiyuki, Beck Florian, Aufderheide Antje, Förster Friedrich, Danev Radostin, Baumeister Wolfgang}
Science. 2015 Jan 23
doi: 10.1126/science.1261197

 

B05: Molecular perspectives on protein adenylylation.
^{Hedberg Christian, Itzen Aymelt}
ACS Chem Biol. 2015 Jan 16
doi: 10.1021/cb500854e 

 

A01: Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography.
^{Engel Benjamin D., Schaffer Miroslava, Kuhn Cuellar Luis, Villa Elizabeth, Plitzko Jürgen M., Baumeister Wolfgang}
Elife. 2015 Jan 13
doi: 10.7554/eLife.04889

 

A06: Assays to characterize molecular chaperone function in vitro.
^{Haslbeck Martin, Buchner Johannes}
Mol Biol. 2015
doi: 10.1007/978-1-4939-2522-3_3