Publikationen des SFB1035 von 2019

A06/A09/B08: The heat shock response in yeast maintains protein homeostasis by chaperoning and replenishing proteins.
^{Mühlhofer Moritz, Berchtold Evi, Stratil Chris G., Csaba Gergely, Kunold Elena, Bach Nina C. Sieber Stephan A., Haslbeck Martin, Zimmer Ralf, Buchner Johannes}
Cell Rep. 2019 Dec 24
doi: 10.1016/j.celrep.2019.11.109

 

B07: Structural insight into IAPP-derived amyloid inhibitors and their mechanism of action.
^{Niu Zheng, Prade Elke, Malideli Eleni, Hille Kathleen, Jussupow Alexander, Mideksa Yonatan G., Yan Li-Mei, Qian Chen, Fleisch Markus, Messias Ana C., Sarkar Riddhiman, Sattler Michael, Lamb Don C., Feige Matthias J., Camilloni Carlo, Kapurniotu Aphrodite, Reif Bernd}
Angew Chem Int Ed Engl. 2019 Dec 21
doi: 10.1002/anie.201914559
 

A06/B02/B07: The structure and oxidation of the eye lens chaperone aA-crystallin.
^{Kaiser Christoph J. O., Peters Carsten, Schmid Philipp W. N., Stavropoulou Maria, Zou Juan, Dahiya Vinay, Mymrikov Evgeny V., Rockel Beate, Asami Sam, Haslbeck Martin, Rappsilber Juri, Reif Bernd, Zacharias Martin, Buchner Johannes, Weinkauf Sevil}
Nat Struct Mol Biol. 2019 Dec
doi: 10.1038/s41594-019-0332-9
 

A05: An active, ligand-responsive pulling geometry reports on internal signaling between subdomains of the DnaK nucleotide-binding domain in single-molecule mechanical experiments.
^{Meinhold Sarah , Bauer Daniela , Huber Jonas, Merkel Ulrich, Weißl Andreas, Žoldák Gabriel, Rief Matthias}
Biochemistry. 2019 Nov 26
doi: 10.1021/acs.biochem.9b00155

 

B10: Photo-induced and rapid labeling of tetrazine-bearing proteins via cyclopropenone-caged bicyclononynes.
^{Mayer Susanne V., Murnauer Anton, von Wrisberg Marie-Kristin, Jokisch Marie-Lena, Lang Kathrin}
Angew Chem Int Ed Engl. 2019 Oct 28
doi: 10.1002/anie.201908209

 

A09/Z1: Cryo-EM structure of the ClpXP protein degradation machinery.
^{Gatsogiannis Christos, Balogh Dora, Merino Felipe, Sieber Stephan A., Raunser Stefan}
Nat Struct Mol Biol. 2019 Oct
doi: 10.1038/s41594-019-0304-0

 

B11/A03/Z1: The molecular basis of chaperone-mediated interleukin 23 assembly control.
^{Meier Susanne, Bohnacker Sina, Klose Carolin J., López Abraham, Choe Christian A., Schmid Philipp W. N., Bloemeke Nicolas, Rührnößl Florian, Haslbeck Martin, Esser-von Bieren Julia, Sattler Michael, Huang Po-Ssu, Feige Matthias J.}
Nat Commun. 2019 Sep 11
doi: 10.1038/s41467-019-12006-x
https://www.ncbi.nlm.nih.gov/pubmed/?term=31511508

 

A03/B12: Autophosphorylation activates c-Src kinase through global structural rearrangements.
^{Boczek Edgar E., Luo Qi, Dehling Marco, Röpke Michael, Mader Sophie L., Seidl Andreas, Kaila Ville R. I., Buchner Johannes}
J Biol Chem. 2019 Aug 30
doi: 10.1074/jbc.RA119.008199
 

B06: Blocking inflammasome activation caused by ß-amyloid peptide (Aß) and islet amyloid polypeptide (IAPP) through an IAPP mimic.
^{Aftabizadeh Maryam, Tatarek-Nossol Marianna, Andreetto Erika, El Bounkari Omar, Kipp Markus, Beyer Cordian, Latz Eicke, Bernhagen Jürgen, Kapurniotu Aphrodite}
ACS Chem Neurosci. 2019 Aug 21
doi: 10.1021/acschemneuro.9b00260
 

B02/B05: Phosphorylation of Ser111 in Rab8a modulates Rabin8-dependent activation by perturbation of side chain interaction networks.
^{Pourjafar-Dehkordi Danial, Vieweg Sophie, Itzen Aymelt, Zacharias Martin}
Biochemistry. 2019 Aug 20
doi: 10.1021/acs.biochem.9b00516
 

A11: Quantitative single-molecule three-color Förster resonance energy transfer by photon distribution analysis.
^{Barth Anders, Voith von Voithenberg Lena, Lamb Don C.}
J Phys Chem B. 2019 Aug 15
doi: 10.1021/acs.jpcb.9b02967
 

A03/A05: The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.
^{Girstmair Hannah, Tippel Franziska, López Abraham, Tych Katarzyna, Stein Frank, Haberkant Per, Schmid Philipp Werner Norbert, Helm Dominic, Rief Matthias, Sattler Michael, Buchner Johannes}
Nat Commun. 2019 Aug 9
doi: 10.1038/s41467-019-11518-w

 

A12: The Hsp70 chaperone system stabilizes a thermo-sensitive subproteome in E. coli.
^{Zhao Liang, Vecchi Giulia, Vendruscolo Michele, Körner Roman, Hayer-Hartl Manajit, Hartl F. Ulrich}
Cell Rep. 2019 Jul 30
doi: 10.1016/j.celrep.2019.06.081

A07/B03: The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
^{Lingaraju Mahesh, Johnsen Dennis, Schlundt Andreas, Langer Lukas M., Basquin Jérôme , Sattler Michael, Heick Jensen Torben, Falk Sebastian, Conti Elena}
Nat Commun. 2019 Jul 29
doi: 10.1038/s41467-019-11339-x

 

B11/B10/A02: Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells.
^{Hohl Adrian, Mideksa Yonatan G., Karan Ram, Akal Anastassja, Vogler Malvina, Groll Michael, Rueping Magnus, Lang Kathrin , Feige Matthias J., Eppinger Jörg}
Chembiochem. 2019 Jul 15
doi: 10.1002/cbic.201900015

B03/B12: Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states.
^{Jagtap Pravin Kumar Ankush, Asami Sam, Sippel Claudia, Kaila Ville R. I., Hausch Felix, Sattler Michael}
Angew Chem Int Ed Engl. 2019 Jul 8
doi: 10.1002/anie.201902994
 

B11/B02: An interspecies analysis reveals molecular construction principles of interleukin 27.
^{Müller Stephanie I., Aschenbrenner Isabel, Zacharias Martin, Feige Matthias J.}
J Mol Biol. 2019 May 31
doi: 10.1016/j.jmb.2019.04.032
 

A07: Molecular basis for poly(A) RNP architecture and recognition by the Pan2-Pan3 deadenylase.
^{Schäfer Ingmar B., Yamashita Masami, Schuller Jan Michael, Schüssler Steffen, Reichelt Peter, Strauss Mike, Conti Elena}
Cell. 2019 May 30
doi: 10.1016/j.cell.2019.04.013
 

A09: Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer-hexamer assembly.
^{Lakemeyer Markus, Bertosin Eva, Möller Friederike, Balogh Dóra, Strasser Ralf, Dietz Hendrik, Sieber Stephan A.}
Angew Chem Int Ed Engl. 2019 May 20
doi: 10.1002/anie.201901056

 

A03/A11: Coordinated conformational processing of the tumor suppressor protein p53 by the Hsp70 and Hsp90 chaperone machineries.
^{Dahiya Vinay, Agam Ganesh, Lawatscheck Jannis, Rutz Daniel Andreas, Lamb Don C., Buchner Johannes}
Mol Cell. 2019 May 16
doi: 10.1016/j.molcel.2019.03.026

A06: The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation-suppressing activity.
^{Wu Di, Vonk Jan J., Salles Felix, Vonk Danara, Haslbeck Martin, Melki Ronald, Bergink Steven, Kampinga Harm H.}
J Biol Chem. 2019 May 16
doi: 10.1074/jbc.RA118.007117
 

A02/B12: Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens.
^{Zhou Qiuqin, Bräuer Alois, Adihou Helène, Schmalhofer Maximilian, Saura Patricia, Grammbitter Gina L. C.,  Kaila Ville R. I., Groll Michael, Bode Helge B.}
Chem Sci. 2019 May 14
doi: 10.1039/c9sc00749k
 

B10: Expanding the genetic code with a lysine derivative bearing an enzymatically removable phenylacetyl group.
^{Reille-Seroussi Marie, Mayer Susanne V., Dörner Wolfgang, Lang Kathrin, Mootz Henning D.}
Chem Commun (Camb). 2019 Apr 18
doi: 10.1039/c9cc00475k
 

A12: Chaperone function of Hgh1 in the biogenesis of eukaryotic elongation factor 2.
^{Mönkemeyer Leonie, Klaips Courtney L., Balchin David, Körner Roman, Hartl F. Ulrich, Bracher Andreas}
Mol Cell. 2019 Apr 4
doi: 10.1016/j.molcel.2019.01.034
 

B03: Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
^{Pabis Marta, Corsini Lorenzo, Vincendeau Michelle, Tripsianes Konstantinos, Gibson Toby J., Brack-Werner Ruth, Sattler Michael}
Nucleic Acids Res. 2019 Mar 20
doi: 10.1093/nar/gkz185

 

A03/A02: The co-chaperone Cns1 and the recruiter protein Hgh1 link Hsp90 to translation elongation via chaperoning elongation factor 2.
^{Schopf Florian H., Huber Eva M., Dodt Christopher, López Abraham, Biebl Maximilian M. Rutz Daniel A., Mühlhofer Moritz, Richter Gesa, Madl Tobias, Sattler Michael, Groll Michael, Buchner Johannes}
Mol Cell. 2019 Mar 8
doi: 10.1016/j.molcel.2019.02.011

 

A12: Improved recombinant expression and purification of functional plant Rubisco.
^{Wilson Robert H., Thieulin-Pardo Gabriel, Hartl F. Ulrich, Hayer-Hartl Manajit}
FEBS Lett. 2019 Mar
doi: 10.1002/1873-3468.13352
 

B10/B12: Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase.
^{Fottner Maximilian,Brunner  Andreas-David, Bittl Verena, Horn-Ghetko Daniel, Jussupow Alexander, Kaila Ville R. I., Bremm Anja, Lang Kathrin}
Nat Chem Biol. 2019 Mar
doi: 10.1038/s41589-019-0227-4

 

A03: Structure, function, and regulation of the Hsp90 machinery.
^{Biebl Maximilian, Buchner Johannes}
Cold Spring Harb Perspect Biol. 2019 Feb 11
doi: 10.1101/cshperspect.a034017

 

A12: Rubisco condensate formation by CcmM in ß-carboxysome biogenesis.
^{Wang Huping, Yan Xiao; Aigner Harald, Bracher Andreas, Nguyen Nghiem D., Hee Wei Yih, Long Benedict M., Price G. Dean, Hartl F. Ulrich, Hayer-Hartl Manajit}
Nature. 2019 Feb
doi: 10.1038/s41586-019-0880-5
 

Z1/B03/A07: HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
^{Pabis Marta, Popowicz Grzegorz M., Stehle Ralf, Fernández-Ramos David, Asami Sam, Warner Lisa, García-Mauriño Sofía M., Schlundt Andreas, L. Martínez-Chantar María, Díaz-Moreno Irene, Sattler Michael}
Nucleic Acids Res. 2019 Jan 25
doi: 10.1093/nar/gky1138

 

B13/B02: The N-terminal segment of the voltage-dependent anion channel: A possible membrane-bound intermediate in pore unbinding.
^{Reif Maria, Fischer Moritz, Fredriksson Kai, Hagn Franz, Zacharias Martin}
J Mol Biol. 2019 Jan 18
doi: 10.1016/j.jmb.2018.09.015

 

A09/A10: Chemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in situ interaction networks.
^{Fux Anja, Korotkov Vadim S., Schneider Markus, Antes Iris, Sieber Stephan A.}
Cell Chem Biol. 2019 Jan 17
doi: 10.1016/j.chembiol.2018.10.007

 

B11/B02: A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine.
^{Müller Stephanie I., Friedl Antonie, Aschenbrenner Isabel, Esser-von Bieren Julia, Zacharias Martin, Devergne Odile, Feige Matthias J.}
Proc Natl Acad Sci USA. 2019 Jan 16
doi: 10.1073/pnas.1816698116

 

A11: Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP-DNA dissociation.
^{Heiss Gregor, Ploetz Evelyn, Voith von Voithenberg Lena, Viswanathan Ramya, Glaser Samson, Schluesche Peter, Madhira Sushi, Meisterernst Michael, Auble David T., Lamb Don C.}
Nucleic Acids Res. 2019 Jan 15
doi: 10.1093/nar/gky1322

 

A01: Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.
^{Majumder Parijat, Rudack Till, Beck Florian, Danev Radostin, Pfeifer Günter, Nagy István, Baumeister Wolfgang}
Proc Natl Acad Sci USA. 2019 Jan 8
doi: 10.1073/pnas.1817752116